Options/ recommendations/ thoughts re TRD (treatment-resistant depression), especially concerning atypical and bipolar spectrum depression.     —Robert D. McMullen, MD   7/28/2019          THE BIPOLAR SPECTRUM:   atypical depression and Bipolar II Disorder and their treatment.   Atypical Depression often ends up as TRD, sometimes because of the very things used to treat it: serotonin medications.  What is discussed below